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XB-ART-2372
Dev Cell 2005 Feb 01;82:136-7. doi: 10.1016/j.devcel.2005.01.006.
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ER retention of signaling modules.

Schlesinger A , Shilo BZ .


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A novel strategy for controlling developmental signaling pathways, which uses specific ER retention mechanisms, has emerged from several recent studies. A paper by Yamamoto et al. (2005) identifies a new protein termed Shisa that inhibits both Wnt- and FGF-signaling pathways during Xenopus gastrulation by mediating ER retention of the Wnt receptor Frizzled and the FGF receptor.

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Species referenced: Xenopus
Genes referenced: shisa1 tbx2

References :
Yamamoto, Shisa promotes head formation through the inhibition of receptor protein maturation for the caudalizing factors, Wnt and FGF. 2005, Pubmed, Xenbase