Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-ART-23762
Dev Biol 1992 May 01;1511:306-16. doi: 10.1016/0012-1606(92)90235-9.
Show Gene links Show Anatomy links

Characterization of a Xenopus oocyte factor that binds to a developmentally regulated cis-element in the TFIIIA gene.

Pfaff SL , Taylor WL .


???displayArticle.abstract???
TFIIIA mRNA expression is developmentally regulated during Xenopus oogenesis. We have identified a positive-acting cis-element in the TFIIIA gene located between -671 and -629 with respect to the mRNA initiation site, termed element 3. Element 3 contributes to the efficient transcription of the TFIIIA gene in stage III oocytes, but is inactive in the normal context of the TFIIIA gene in stage VI oocytes. A trans-acting factor, termed B3, in immature ovary extracts binds to a region within element 3 containing four repeats of the consensus nucleotide sequence 5' (T/A)GGTTACT. We discuss how the developmental regulation of B3-element 3 function could be achieved in the context of the TFIIIA gene during oogenesis.

???displayArticle.pubmedLink??? 1577195
???displayArticle.link??? Dev Biol
???displayArticle.grants??? [+]

Species referenced: Xenopus
Genes referenced: gtf3a