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Science. April 17, 1992; 256 (5055): 385-7.

Appearance of water channels in Xenopus oocytes expressing red cell CHIP28 protein.

Preston GM , Carroll TP , Guggino WB , Agre P .

Water rapidly crosses the plasma membrane of red blood cells (RBCs) and renal tubules through specialized channels. Although selective for water, the molecular structure of these channels is unknown. The CHIP28 protein is an abundant integral membrane protein in mammalian RBCs and renal proximal tubules and belongs to a family of membrane proteins with unknown functions. Oocytes from Xenopus laevis microinjected with in vitro-transcribed CHIP28 RNA exhibited increased osmotic water permeability; this was reversibly inhibited by mercuric chloride, a known inhibitor of water channels. Therefore it is likely that CHIP28 is a functional unit of membrane water channels.

PubMed ID: 1373524
Article link: Science.
Grant support: DK32753 NIDDK NIH HHS , HL33991 NHLBI NIH HHS , HL48268 NHLBI NIH HHS

Genes referenced: aqp1

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