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XB-ART-23913
FEBS Lett 1992 Mar 24;2991:5-9.
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Endogenous Xenopus-oocyte Ca-channels are regulated by protein kinases A and C.

Bourinet E , Fournier F , Nargeot J , Charnet P .


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Calcium entry into Xenopus oocyte occurs mainly through voltage-dependent calcium channels. These channels were characterized as belonging to a particular type of calcium channel insensitive to dihydropyridines, omega-conotoxin, and Agelenopsis aperta venom, but blocked by divalent cations (Co, Cd, Ni). Intracellular injection of cAMP, or bath application of phorbol ester, induced a marked increase in calcium current amplitude and a slowing of the inactivation time-course. Despite their different pharmacology, endogenous calcium channels, like cardiac or neuronal calcium channels, could be thus regulated by protein kinases A and C.

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Genes referenced: camp