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Science February 21, 1992; 255 (5047): 989-91.

The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor.

de Vries C , Escobedo JA , Ueno H , Houck K , Ferrara N , Williams LT .

The fms-like tyrosine kinase (Flt) is a transmembrane receptor in the tyrosine kinase family. Expression of flt complementary DNA in COS cells conferred specific, high-affinity binding of vascular endothelial growth factor, also known as vascular permeability factor (VEGF-VPF), a factor that induces vascular permeability when injected in the guinea pig skin and stimulates endothelial cell proliferation. Expression of Flt in Xenopus laevis oocytes caused the oocytes to release calcium in response to VEGF-VPF. These findings show that flt encodes a receptor for VEGF-VPF.

PubMed ID: 1312256
Article link: Science
Grant support: [+]
Genes referenced: csf1r flt1 vegfa

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