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XB-ART-24071
J Biol Chem 1992 Jan 25;2673:1792-7.
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Cloning and expression of a cardiac/brain beta subunit of the L-type calcium channel.

Perez-Reyes E , Castellano A , Kim HS , Bertrand P , Baggstrom E , Lacerda AE , Wei XY , Birnbaumer L .


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The skeletal muscle dihydropyridine receptor/Ca2+ channel is composed of five protein components (alpha 1, alpha 2 delta, beta, and gamma). Only two such components, alpha 1 and alpha 2, have been identified in heart. The present study reports the cloning and expression of a novel beta gene that is expressed in heart, lung, and brain. Coexpression of this beta with a cardiac alpha 1 in Xenopus oocytes causes the following changes in Ca2+ channel activity: it increases peak currents, accelerates activation kinetics, and shifts the current-voltage relationship toward more hyperpolarized potentials. It also increases dihydropyridine binding to alpha 1 in COS cells. These results indicate that the cardiac L-type Ca2+ channel has a similar subunit structure as in skeletal muscle, and provides evidence for the modulatory role of the beta subunit.

???displayArticle.pubmedLink??? 1370480
???displayArticle.link??? J Biol Chem
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