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J Biol Chem. April 8, 2005; 280 (14): 14122-9.

DRAGON, a bone morphogenetic protein co-receptor.

Samad TA , Rebbapragada A , Bell E , Zhang Y , Sidis Y , Jeong SJ , Campagna JA , Perusini S , Fabrizio DA , Schneyer AL , Lin HY , Brivanlou AH , Attisano L , Woolf CJ .

Bone morphogenetic proteins (BMPs) are members of the transforming growth factor (TGF)beta superfamily of ligands that regulate many crucial aspects of embryonic development and organogenesis. Unlike other TGFbeta ligands, co-receptors for BMP ligands have not been described. Here we show that DRAGON, a glycosylphosphatidylinositol-anchored member of the repulsive guidance molecule family, which is expressed early in the developing nervous system, enhances BMP but not TGFbeta signaling. DRAGON binds directly to BMP2 and BMP4 but not to BMP7 or other TGFbeta ligands. The enhancing action of DRAGON on BMP signaling is also reduced by administration of Noggin, a soluble BMP antagonist, indicating that the action of DRAGON is ligand-dependent. DRAGON associates directly with BMP type I (ALK2, ALK3, and ALK6) and type II (ActRII and ActRIIB) receptors, and its signaling is reduced by dominant negative Smad1 and ALK3 or -6 receptors. In the Xenopus embryo, DRAGON both reduces the threshold of the ability of Smad1 to induce mesodermal and endodermal markers and alters neuronal and neural crest patterning. The direct interaction of DRAGON with BMP ligands and receptors indicates that it is a BMP co-receptor that potentiates BMP signaling.

PubMed ID: 15671031
Article link: J Biol Chem.

Genes referenced: acta1 acvr1 acvr2a acvr2b acvrl1 alk babam2 bmp2 bmp4 bmp7.1 bmp7.2 bmpr1a bmpr1b csrp3 gnpda1 inhba nkx2-5 nog nr2e1 nrp1 otx2 pklr rgma rgmb smad1 sox2 tbxt tgfb1 tubb2b twist1

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