Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
Expression of adult and tadpole specific globin genes from Xenopus laevis in transgenic mice.
Dillon N
,
Kollias G
,
Grosveld F
,
Williams JG
.
???displayArticle.abstract???
Transgenic mice were generated which carried the adult alpha and beta-globin genes and the major tadpole specific beta-globin gene of Xenopus laevis. The adult specific alpha and beta genes were found to express in erythroid tissues in adult mice, while the major tadpole specific beta gene (beta T1) was expressed in blood from 12.5 day embryos. The pattern of expression of the beta T1 gene during mouse development was consistent with its being regulated as an embryonic globin gene in the mouse. This observation suggests that some of the factors mediating globin switching have been conserved during the evolution of modern amphibia and mammals and raises interesting questions concerning the evolution of vertebrate globin gene switching.
Banville,
The nucleotide sequence of the mRNA encoding a tadpole beta-globin polypeptide of Xenopus laevis.
1983, Pubmed,
Xenbase
Banville,
The nucleotide sequence of the mRNA encoding a tadpole beta-globin polypeptide of Xenopus laevis.
1983,
Pubmed
,
Xenbase
Banville,
Developmental changes in the pattern of larval beta-globin gene expression in Xenopus laevis. Identification of two early larval beta-globin mRNA sequences.
1985,
Pubmed
,
Xenbase
Banville,
The pattern of expression of the Xenopus laevis tadpole alpha-globin genes and the amino acid sequence of the three major tadpole alpha-globin polypeptides.
1985,
Pubmed
,
Xenbase
Bendig,
Differential expression of the Xenopus laevis tadpole and adult beta-globin genes when injected into fertilized Xenopus laevis eggs.
1984,
Pubmed
,
Xenbase
Chirgwin,
Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease.
1979,
Pubmed
Goodman,
Darwinian evolution in the genealogy of haemoglobin.
1975,
Pubmed
Gorr,
Close tetrapod relationships of the coelacanth Latimeria indicated by haemoglobin sequences.
1991,
Pubmed
,
Xenbase
Grosveld,
Position-independent, high-level expression of the human beta-globin gene in transgenic mice.
1987,
Pubmed
Hentschel,
Analysis of Xenopus laevis globins during development and erythroid cell maturation and the construction of recombinant plasmids containing sequences derived from adult globin mRNA.
1979,
Pubmed
,
Xenbase
Hosbach,
The Xenopus laevis globin gene family: chromosomal arrangement and gene structure.
1983,
Pubmed
,
Xenbase
Jeffreys,
Linkage of adult alpha- and beta-globin genes in X. laevis and gene duplication by tetraploidization.
1980,
Pubmed
,
Xenbase
Kollias,
Regulated expression of human A gamma-, beta-, and hybrid gamma beta-globin genes in transgenic mice: manipulation of the developmental expression patterns.
1986,
Pubmed
Meyerhof,
The primary structure of the larval beta 1-globin gene of Xenopus laevis and its flanking regions.
1984,
Pubmed
,
Xenbase
Patient,
Internal organization of the major adult alpha- and beta-globin genes of X. laevis.
1980,
Pubmed
,
Xenbase
Reitman,
Site-independent expression of the chicken beta A-globin gene in transgenic mice.
,
Pubmed
Watt,
Hemoglobins of the tadpole of the bullfrog, Rana catesbeiana. Amino acid sequence of the beta chain of a major component.
1980,
Pubmed
Whitelaw,
Regulated expression of globin chains and the erythroid transcription factor GATA-1 during erythropoiesis in the developing mouse.
1990,
Pubmed
Wong,
Adult hemoglobins are synthesized in murine fetal hepatic erythropoietic cells.
1983,
Pubmed
