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XB-ART-25043
FEBS Lett 1991 Feb 25;2792:256-60.
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Modulation of a Shaker potassium A-channel by protein kinase C activation.

Moran O , Dascal N , Lotan I .


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Brain fast transient K+ channel (A channel) is known to be modulated by PKC activation. We studied, by two-electrode voltage clamp, the molecular mechanism of modulation by PKC activation of A-channels expressed in Xenopus oocytes from the Shaker H4 clone. The modulation is inhibitory affecting primarily the maximal conductance of the channels. A secondary effect is a small change in the voltage-dependence of activation and inactivation of the channel.

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