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XB-ART-25271
Dev Comp Immunol 1991 Jan 01;154:319-28.
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Splenocyte response to T cell-derived cytokines in thymectomized Xenopus.

Turner SL , Horton TL , Ritchie P , Horton JD .


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A miniaturized, "hanging-drop" bioassay reveals that splenocytes from early-thymectomized (Tx) Xenopus can respond (by enhanced thymidine incorporation) to thymic-dependent "cytokines" generated in PHA- or alloantigen-stimulated cultures. Preliminary evidence, using fluorescence activated cell sorting, indicates that surface IgM- splenocytes, rather than sIgM+ cells, from Tx toads are sensitive to the crude, splenocyte-derived, active supernatants. Although these responsive cells display residual, but low, reactivity to PHA, their thymus independence is suggested by flow cytometric observations using the anti-T cell monoclonal antibody XT-1. The development of "T-like" cells in Tx Xenopus is discussed.

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Species referenced: Xenopus
Genes referenced: ighx