Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-ART-25366
Science 1990 Dec 07;2504986:1416-8.
Show Gene links Show Anatomy links

Requirement of ets-2 expression for Xenopus oocyte maturation.

Chen ZQ , Burdett LA , Seth AK , Lautenberger JA , Papas TS .


???displayArticle.abstract???
A molecular clone of the Xenopus laevis ets-2 gene was isolated from an oocyte complementary DNA library. The amount of messenger RNA (mRNA) in each oocyte or embryo was almost constant during oogenesis and was maintained until the blastula stage of embryonic development, indicating that the observed 3.2-kilobase transcript is a maternal message. The only normal adult tissue in which ets-2 mRNA was detected was the ovary. Injection of antisense oligonucleotides homologous to the ets-2 sequence into oocytes led to degradation of the mRNA and blocked hormone-induced germinal vesicle breakdown. The ets-2 product is thus required for the meiotic maturation of Xenopus oocytes.

???displayArticle.pubmedLink??? 2255913
???displayArticle.link??? Science


Species referenced: Xenopus laevis
Genes referenced: ets2