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XB-ART-2541
Dev Biol January 15, 2005; 277 (2): 296-315.

Olfactory and lens placode formation is controlled by the hedgehog-interacting protein (Xhip) in Xenopus.

Cornesse Y , Pieler T , Hollemann T .


Abstract
The integration of multiple signaling pathways is a key issue in several aspects of embryonic development. In this context, extracellular inhibitors of secreted growth factors play an important role, which is to antagonize specifically the activity of the corresponding signaling molecule. We provide evidence that the Hedgehog-interacting protein (Hip) from Xenopus, previously described as a Hedgehog-specific antagonist in the mouse, interferes with Wnt-8 and eFgf/Fgf-8 signaling pathways as well. To address the function of Hip during early embryonic development, we performed gain- and loss-of-function studies in the frog. Overexpression of Xhip or mHip1 resulted in a dramatic increase of retinal structures and larger olfactory placodes primarily at the expense of other brain tissues. Furthermore, loss of Xhip function resulted in a suppression of olfactory and lens placode formation. Therefore, the localized expression of Xhip may counteract certain overlapping signaling activities, which inhibit the induction of distinct sensory placodes.

PubMed ID: 15617676
Article link: Dev Biol

Genes referenced: bmp4 chrd.1 dlx3 egr2 elavl1 emx2 en2 fgf4 fgf8 gal.2 grn hhip mapk1 nodal3.1 nodal3.2 otx2 pax2 pax6 pitx1 pitx3 ptch1 rax rho sdhd shh sia1 six3 slc5a5 tbx2 tbxt vax1 wnt3a wnt8a
Morpholinos: hhip MO1


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