Jegalian BG and De Robertis EM (1990), The Xenopus laevis Hox 2.1 homeodomain protein ...

XB-ART-25415

Int J Dev Biol 1990 Dec 01;344:453-6.

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The Xenopus laevis Hox 2.1 homeodomain protein is expressed in a narrow band of the hindbrain.

Jegalian BG , De Robertis EM .

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The expression pattern of the Xenopus homeodomain protein Hox 2.1 during development was determined using an affinity-purified antibody directed against a carboxyterminal peptide. Nuclear staining was detected in a very narrow band of the hindbrain. This pattern was compared to that of the previously described Xenopus gene XIHbox 1 in serial sections and found to be more anterior than the XIHbox 1 long protein expression but overlapping with that of the short protein. Xenopus Hox 2.1 protein expression is restricted to a much narrower antero-posterior band than that reported for mouse Hox 2.1 RNA expression by in situ hybridization.

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Species referenced: Xenopus laevis
Genes referenced: hoxb5 hoxb7 hoxc6 tbx2
???displayArticle.antibodies??? HoxB5 Ab1 Hoxc6 Ab3 Hoxc6 Ab4 Hoxc6 Ab5

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	Fig. 2. Sagittal sections of X. laevis stage 46 tadpoles through the hindbrain and the anterior spinal cord were stained with Hox2.1 (A) and with XlHbox 1 long protein antibody (B). Note that Hox2.1 is expressed in a narrow band of hindbrain neurons. Bar = 100um
	Fig. 3. Transverse sections of X. laevis stage 46 tadpoles were stained with antibodies. Serial sections at the level of the hindbrain (A-C): at the level of anterior spinal cord (D-F). (A) and (D) show staining with X laevis Hox 2.1 antibodies. (B) and (E) with XlHbox1 long protein-specific antibodies, and (C) and (F) with XlHbox 1 common antibodies (Oliver et al. 1988). Bar=50um.