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XB-ART-25462
Science 1990 Nov 09;2504982:800-2.
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Region-specific neural induction of an engrailed protein by anterior notochord in Xenopus.

Hemmati-Brivanlou A , Stewart RM , Harland RM .


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Anterior-specific neural induction can be assayed by means of an antibody that recognizes the Xenopus homeobox-containing protein En-2. The En-2 antigen is an excellent early marker, since it is present as a discrete band in the anterior neural plate of neurula embryos. Regional induction was assayed by combining dorsal mesoderm with competent ectoderm. Anterior notochord from the early neurula induced En-2 frequently, while posterior notochord induced En-2 less frequently. Presumptive somitic mesoderm and presumptive head mesoderm, though they induced neural tissue, were not strong inducers of En-2. Thus, anterior notochord may be the primary mesodermal tissue responsible for the patterning of the anterior neural plate.

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Species referenced: Xenopus
Genes referenced: en2