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EMBO J July 1, 1990; 9 (7): 2085-93.

OP-1 cDNA encodes an osteogenic protein in the TGF-beta family.

Ozkaynak E , Rueger DC , Drier EA , Corbett C , Ridge RJ , Sampath TK , Oppermann H .

Amino acid sequences of two tryptic peptides derived from enriched bovine osteogenic protein preparations revealed considerable homology to two members of the TGF-beta (transforming growth factor beta) supergene family, DPP (decapentaplegic protein) of Drosophila and Vg-1 (vegetal protein) of Xenopus. Building upon this information we constructed a synthetic consensus gene to use as a probe to screen human genomic libraries. This resulted in the isolation of three interrelated genes. Among these were BMP-2b and BMP-3 which have recently been described by others. The third gene, termed OP-1 (osteogenic protein one), is new and was subsequently shown to encode the human homolog of a major component of bovine osteogenic protein. The genomic clones were used to isolate the corresponding complementary DNA (cDNA) clones. Sequence analysis indicates that OP-1 is a relative of the murine Vgr-1 (Vg-1 related gene). This report describes the cDNA structure and putative amino acid sequence of OP-1.

PubMed ID: 2357959
PMC ID: PMC551926
Article link:

Species referenced: Xenopus laevis
Genes referenced: bmp3 bmp6 bmp7.1 dspp gdf1 tgfb1

References [+] :
Brunner, Recombinant type 1 transforming growth factor beta precursor produced in Chinese hamster ovary cells is glycosylated and phosphorylated. 1988, Pubmed