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XB-ART-26075
Cell February 9, 1990; 60 (3): 487-94.

Cyclin is a component of maturation-promoting factor from Xenopus.

Gautier J , Minshull J , Lohka M , Glotzer M , Hunt T , Maller JL .


Abstract
Highly purified maturation-promoting factor (MPF) from Xenopus eggs contains both cyclin B1 and cyclin B2 as shown by Western blotting and immunoprecipitation using Xenopus anti-B-type cyclin antibodies. Immunoprecipitates with these antibodies display the histone H1 kinase activity characteristic of MPF, for which exogenously added B1 and B2 cyclins are both substrates. Protein kinase activity against cyclin oscillates in maturing oocytes and activated eggs with the same kinetics as p34cdc2 kinase activity. These data indicate that B-type cyclin is the other component of MPF besides p34cdc2.

PubMed ID: 1967981
Article link: Cell


Species referenced: Xenopus laevis
Genes referenced: cdk1