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EMBO J
2005 Jan 12;241:73-84. doi: 10.1038/sj.emboj.7600460.
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FGF-20 and DKK1 are transcriptional targets of beta-catenin and FGF-20 is implicated in cancer and development.
Chamorro MN
,
Schwartz DR
,
Vonica A
,
Brivanlou AH
,
Cho KR
,
Varmus HE
.
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beta-catenin is the major effector of the canonical Wnt signaling pathway. Mutations in components of the pathway that stabilize beta-catenin result in augmented gene transcription and play a major role in many human cancers. We employed microarrays to identify transcriptional targets of deregulated beta-catenin in a human epithelial cell line (293) engineered to produce mutant beta-catenin and in ovarian endometrioid adenocarcinomas characterized with respect to mutations affecting the Wnt/beta-catenin pathway. Two genes strongly induced in both systems-FGF20 and DKK1-were studied in detail. Elevated levels of FGF20 RNA were also observed in adenomas from mice carrying the Apc(Min)allele. Both XFGF20 and Xdkk-1 are expressed early in Xenopus embryogenesis under the control of the Wnt signaling pathway. Furthermore, FGF20 and DKK1 appear to be direct targets for beta-catenin/TCF transcriptional regulation via LEF/TCF-binding sites. Finally, by using small inhibitory RNAs specific for FGF20, we show that continued expression of FGF20 is necessary for maintenance of the anchorage-independent growth state in RK3E cells transformed by beta-catenin, implying that FGF-20 may be a critical element in oncogenesis induced by the Wnt signaling pathway.
Bienz,
Linking colorectal cancer to Wnt signaling.
2000, Pubmed
Bienz,
Linking colorectal cancer to Wnt signaling.
2000,
Pubmed
Brannon,
A beta-catenin/XTcf-3 complex binds to the siamois promoter to regulate dorsal axis specification in Xenopus.
1997,
Pubmed
,
Xenbase
Brummelkamp,
A system for stable expression of short interfering RNAs in mammalian cells.
2002,
Pubmed
Carnac,
The homeobox gene Siamois is a target of the Wnt dorsalisation pathway and triggers organiser activity in the absence of mesoderm.
1996,
Pubmed
,
Xenbase
Christian,
Xwnt-8, a Xenopus Wnt-1/int-1-related gene responsive to mesoderm-inducing growth factors, may play a role in ventral mesodermal patterning during embryogenesis.
1991,
Pubmed
,
Xenbase
Conacci-Sorrell,
Nr-CAM is a target gene of the beta-catenin/LEF-1 pathway in melanoma and colon cancer and its expression enhances motility and confers tumorigenesis.
2002,
Pubmed
Darken,
Axis induction by wnt signaling: Target promoter responsiveness regulates competence.
2001,
Pubmed
,
Xenbase
Dhulipal,
Ets oncogene family.
1997,
Pubmed
Dickson,
Tyrosine kinase signalling in breast cancer: fibroblast growth factors and their receptors.
2000,
Pubmed
Dunn,
Neural crest-directed gene transfer demonstrates Wnt1 role in melanocyte expansion and differentiation during mouse development.
2000,
Pubmed
Fisher,
Development of a flexible and specific gene delivery system for production of murine tumor models.
1999,
Pubmed
Glinka,
Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction.
1998,
Pubmed
,
Xenbase
Grotewold,
The Wnt antagonist Dickkopf-1 is regulated by Bmp signaling and c-Jun and modulates programmed cell death.
2002,
Pubmed
Hacein-Bey-Abina,
LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1.
2003,
Pubmed
Hamilton,
Difference in XTcf-3 dependency accounts for change in response to beta-catenin-mediated Wnt signalling in Xenopus blastula.
2001,
Pubmed
,
Xenbase
Harland,
Formation and function of Spemann's organizer.
1997,
Pubmed
He,
Identification of c-MYC as a target of the APC pathway.
1998,
Pubmed
Hecht,
Curbing the nuclear activities of beta-catenin. Control over Wnt target gene expression.
2000,
Pubmed
Himly,
The DF-1 chicken fibroblast cell line: transformation induced by diverse oncogenes and cell death resulting from infection by avian leukosis viruses.
1998,
Pubmed
Holland,
A mouse model for glioma: biology, pathology, and therapeutic opportunities.
2000,
Pubmed
Hoppler,
Expression of a dominant-negative Wnt blocks induction of MyoD in Xenopus embryos.
1996,
Pubmed
,
Xenbase
Huelsken,
New aspects of Wnt signaling pathways in higher vertebrates.
2001,
Pubmed
,
Xenbase
Huelsken,
The Wnt signalling pathway.
2002,
Pubmed
Isaacs,
eFGF regulates Xbra expression during Xenopus gastrulation.
1994,
Pubmed
,
Xenbase
Jeffers,
Identification of a novel human fibroblast growth factor and characterization of its role in oncogenesis.
2001,
Pubmed
,
Xenbase
Jho,
Wnt/beta-catenin/Tcf signaling induces the transcription of Axin2, a negative regulator of the signaling pathway.
2002,
Pubmed
Kawano,
Secreted antagonists of the Wnt signalling pathway.
2003,
Pubmed
,
Xenbase
Kessler,
Siamois is required for formation of Spemann's organizer.
1997,
Pubmed
,
Xenbase
Kielman,
Apc modulates embryonic stem-cell differentiation by controlling the dosage of beta-catenin signaling.
2002,
Pubmed
Kofron,
Mesoderm induction in Xenopus is a zygotic event regulated by maternal VegT via TGFbeta growth factors.
1999,
Pubmed
,
Xenbase
Koga,
Characterization of a novel member of the FGF family, XFGF-20, in Xenopus laevis.
1999,
Pubmed
,
Xenbase
Kolligs,
Neoplastic transformation of RK3E by mutant beta-catenin requires deregulation of Tcf/Lef transcription but not activation of c-myc expression.
1999,
Pubmed
Kolligs,
ITF-2, a downstream target of the Wnt/TCF pathway, is activated in human cancers with beta-catenin defects and promotes neoplastic transformation.
2002,
Pubmed
Kratochwil,
FGF4, a direct target of LEF1 and Wnt signaling, can rescue the arrest of tooth organogenesis in Lef1(-/-) mice.
2002,
Pubmed
Lerchner,
Region-specific activation of the Xenopus brachyury promoter involves active repression in ectoderm and endoderm: a study using transgenic frog embryos.
2000,
Pubmed
,
Xenbase
Leung,
Activation of AXIN2 expression by beta-catenin-T cell factor. A feedback repressor pathway regulating Wnt signaling.
2002,
Pubmed
Miller,
Silencing of Wnt signaling and activation of multiple metabolic pathways in response to thyroid hormone-stimulated cell proliferation.
2001,
Pubmed
Moser,
ApcMin, a mutation in the murine Apc gene, predisposes to mammary carcinomas and focal alveolar hyperplasias.
1993,
Pubmed
Munemitsu,
Regulation of intracellular beta-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein.
1995,
Pubmed
Orlando,
Mapping chromosomal proteins in vivo by formaldehyde-crosslinked-chromatin immunoprecipitation.
2000,
Pubmed
Oshima,
Loss of Apc heterozygosity and abnormal tissue building in nascent intestinal polyps in mice carrying a truncated Apc gene.
1995,
Pubmed
Ouko,
Wnt11 signaling promotes proliferation, transformation, and migration of IEC6 intestinal epithelial cells.
2004,
Pubmed
Peifer,
Wnt signaling in oncogenesis and embryogenesis--a look outside the nucleus.
2000,
Pubmed
Polakis,
Wnt signaling and cancer.
2000,
Pubmed
Powers,
Fibroblast growth factors, their receptors and signaling.
2000,
Pubmed
Rabbitts,
Chromosomal translocations and leukaemia: a role for LMO2 in T cell acute leukaemia, in transcription and in erythropoiesis.
1997,
Pubmed
Romagnolo,
Intestinal dysplasia and adenoma in transgenic mice after overexpression of an activated beta-catenin.
1999,
Pubmed
Rousset,
Naked cuticle targets dishevelled to antagonize Wnt signal transduction.
2001,
Pubmed
Rubinfeld,
Association of the APC gene product with beta-catenin.
1993,
Pubmed
Rutzky,
Characterization of a human colonic adenocarcinoma cell line, LS123.
1983,
Pubmed
Schaefer-Klein,
The EV-O-derived cell line DF-1 supports the efficient replication of avian leukosis-sarcoma viruses and vectors.
1998,
Pubmed
Schohl,
A role for maternal beta-catenin in early mesoderm induction in Xenopus.
2003,
Pubmed
,
Xenbase
Schwartz,
Novel candidate targets of beta-catenin/T-cell factor signaling identified by gene expression profiling of ovarian endometrioid adenocarcinomas.
2003,
Pubmed
Semënov,
Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6.
2001,
Pubmed
,
Xenbase
Shimokawa,
Involvement of the FGF18 gene in colorectal carcinogenesis, as a novel downstream target of the beta-catenin/T-cell factor complex.
2003,
Pubmed
Shtutman,
The cyclin D1 gene is a target of the beta-catenin/LEF-1 pathway.
1999,
Pubmed
Smith,
Expression of a Xenopus homolog of Brachyury (T) is an immediate-early response to mesoderm induction.
1991,
Pubmed
,
Xenbase
Spiegelman,
Wnt/beta-catenin signaling induces the expression and activity of betaTrCP ubiquitin ligase receptor.
2000,
Pubmed
Staal,
Wnt target genes identified by DNA microarrays in immature CD34+ thymocytes regulate proliferation and cell adhesion.
2004,
Pubmed
Tago,
Inhibition of Wnt signaling by ICAT, a novel beta-catenin-interacting protein.
2000,
Pubmed
,
Xenbase
Tetsu,
Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells.
1999,
Pubmed
Tian,
The role of the Wnt-signaling antagonist DKK1 in the development of osteolytic lesions in multiple myeloma.
2003,
Pubmed
Vonica,
TCF is the nuclear effector of the beta-catenin signal that patterns the sea urchin animal-vegetal axis.
2000,
Pubmed
,
Xenbase
Vonica,
Zygotic Wnt activity is required for Brachyury expression in the early Xenopus laevis embryo.
2002,
Pubmed
,
Xenbase
Weinmann,
Use of chromatin immunoprecipitation to clone novel E2F target promoters.
2001,
Pubmed
Wilding,
Cyclin D1 is not an essential target of beta-catenin signaling during intestinal tumorigenesis, but it may act as a modifier of disease severity in multiple intestinal neoplasia (Min) mice.
2002,
Pubmed
Willert,
A transcriptional response to Wnt protein in human embryonic carcinoma cells.
2002,
Pubmed
Wu,
Diverse mechanisms of beta-catenin deregulation in ovarian endometrioid adenocarcinomas.
2001,
Pubmed
Zorn,
Regulation of Wnt signaling by Sox proteins: XSox17 alpha/beta and XSox3 physically interact with beta-catenin.
1999,
Pubmed
,
Xenbase
van de Wetering,
The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells.
2002,
Pubmed
