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Pigment Cell Res January 1, 1990; 3 (1): 38-43.

Action of light on frog pigment cells in culture.

Daniolos A , Lerner AB , Lerner MR .

Solar radiation induces numerous biologic effects in skin but the mechanism underlying these responses is poorly understood. To study the etiology of these phenomena, we investigated the effect of light on cultured Xenopus laevis melanophores. Visible light stimulated a marked increase in intracellular cAMP levels within the first minute of irradiation. This light-induced elevation in cAMP was blocked by melatonin and was not seen in fibroblasts irradiated in a similar manner. These data show that the photoresponse of pigment cells from amphibian skin can be mediated by a cAMP-dependent mechanisms and suggest that a unique member of the rhodopsin family is involved in this process.

PubMed ID: 2165596
Article link: Pigment Cell Res
Grant support: [+]

Species referenced: Xenopus laevis
Genes referenced: rho