Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
Primary structure and developmental expression of a large cytoplasmic domain form of Xenopus laevis neural cell adhesion molecule (NCAM).
Krieg PA
,
Sakaguchi DS
,
Kintner CR
.
???displayArticle.abstract???
The neural cell adhesion molecule, (NCAM), is involved in cell-cell interactions during development of the vertebrate nervous system. NCAM exists in multiple protein forms and these are selectively expressed in different cells and at different times during development. Here we report the complete amino acid sequence of the large cytoplasmic form of Xenopus laevis NCAM, derived from a full-length cDNA clone. Using specific probes the expression of different NCAM transcripts during Xenopus embryogenesis has been examined. We find that transcripts encoding the large cytoplasmic domain form of NCAM exist in maternal RNA and that these are the only significant NCAM transcripts present until late gastrula when transcripts encoding the small cytoplasmic domain form of NCAM are first detected. No RNA encoding the small surface domain form of NCAM is detected during early development. These results indicate that the expression of NCAM sequences during early development of Xenopus differs from that described in other species.
Barbas,
Differential splicing and alternative polyadenylation generates distinct NCAM transcripts and proteins in the mouse.
1988, Pubmed
Barbas,
Differential splicing and alternative polyadenylation generates distinct NCAM transcripts and proteins in the mouse.
1988,
Pubmed
Barthels,
Isolation and nucleotide sequence of mouse NCAM cDNA that codes for a Mr 79,000 polypeptide without a membrane-spanning region.
1987,
Pubmed
Cole,
Topographic localization of the heparin-binding domain of the neural cell adhesion molecule N-CAM.
1986,
Pubmed
Cunningham,
Neural cell adhesion molecule: structure, immunoglobulin-like domains, cell surface modulation, and alternative RNA splicing.
1987,
Pubmed
Dickson,
Human muscle neural cell adhesion molecule (N-CAM): identification of a muscle-specific sequence in the extracellular domain.
1987,
Pubmed
Edelman,
Morphoregulatory molecules.
1988,
Pubmed
Feinberg,
A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity.
1983,
Pubmed
Frelinger,
Topography of N-CAM structural and functional determinants. II. Placement of monoclonal antibody epitopes.
1986,
Pubmed
Goridis,
Neural surface antigens during nervous system development.
1983,
Pubmed
Goridis,
Isolation of mouse N-CAM-related cDNA: detection and cloning using monoclonal antibodies.
1985,
Pubmed
Hall,
Phylogeny of a neural cell adhesion molecule.
1985,
Pubmed
He,
Phosphatidylinositol is involved in the membrane attachment of NCAM-120, the smallest component of the neural cell adhesion molecule.
1986,
Pubmed
Hemperly,
Sequence of a cDNA clone encoding the polysialic acid-rich and cytoplasmic domains of the neural cell adhesion molecule N-CAM.
1986,
Pubmed
Hemperly,
cDNA clones of the neural cell adhesion molecule (N-CAM) lacking a membrane-spanning region consistent with evidence for membrane attachment via a phosphatidylinositol intermediate.
1986,
Pubmed
Hoffman,
Chemical characterization of a neural cell adhesion molecule purified from embryonic brain membranes.
1982,
Pubmed
Jacobson,
Induction of neural cell adhesion molecule (NCAM) in Xenopus embryos.
1986,
Pubmed
,
Xenbase
Kintner,
Expression of Xenopus N-CAM RNA in ectoderm is an early response to neural induction.
1987,
Pubmed
,
Xenbase
Kintner,
Effects of altered expression of the neural cell adhesion molecule, N-CAM, on early neural development in Xenopus embryos.
1988,
Pubmed
,
Xenbase
Krieg,
In vitro RNA synthesis with SP6 RNA polymerase.
1987,
Pubmed
Laemmli,
Cleavage of structural proteins during the assembly of the head of bacteriophage T4.
1970,
Pubmed
Levi,
Expression sequences and distribution of two primary cell adhesion molecules during embryonic development of Xenopus laevis.
1987,
Pubmed
,
Xenbase
Melton,
Transcription of cloned tRNA genes and the nuclear partitioning of a tRNA precursor.
1979,
Pubmed
,
Xenbase
Messing,
A new pair of M13 vectors for selecting either DNA strand of double-digest restriction fragments.
1982,
Pubmed
Murray,
Isolation of cDNA clones for the chicken neural cell adhesion molecule (N-CAM).
1984,
Pubmed
Murray,
Alternatively spliced mRNAs code for different polypeptide chains of the chicken neural cell adhesion molecule (N-CAM).
1986,
Pubmed
Nguyen,
Localization of the human NCAM gene to band q23 of chromosome 11: the third gene coding for a cell interaction molecule mapped to the distal portion of the long arm of chromosome 11.
1986,
Pubmed
Owens,
Organization of the neural cell adhesion molecule (N-CAM) gene: alternative exon usage as the basis for different membrane-associated domains.
1987,
Pubmed
Reed,
Rapid transfer of DNA from agarose gels to nylon membranes.
1985,
Pubmed
Sakaguchi,
Growth cone interactions with a glial cell line from embryonic Xenopus retina.
1989,
Pubmed
,
Xenbase
Sanger,
DNA sequencing with chain-terminating inhibitors.
1977,
Pubmed
Santoni,
Analysis of cDNA clones that code for the transmembrane forms of the mouse neural cell adhesion molecule (NCAM) and are generated by alternative RNA splicing.
1987,
Pubmed
Sunshine,
Changes in neural cell adhesion molecule (NCAM) structure during vertebrate neural development.
1987,
Pubmed
,
Xenbase
von Heijne,
Patterns of amino acids near signal-sequence cleavage sites.
1983,
Pubmed
