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Nature December 7, 1989; 342 (6250): 643-8.

Cloning by functional expression of a member of the glutamate receptor family.

Hollmann M , O'Shea-Greenfield A , Rogers SW , Heinemann S .

We have isolated a complementary DNA clone by screening a rat brain cDNA library for expression of kainate-gated ion channels in Xenopus oocytes. The cDNA encodes a single protein of relative molecular mass (Mr) 99,800 which on expression in oocytes forms a functional ion channel possessing the electrophysiological and pharmacological properties of the kainate subtype of the glutamate receptor family in the mammalian central nervous system.

PubMed ID: 2480522
Article link: Nature

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