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XB-ART-26379
Nature November 30, 1989; 342 (6249): 505-11.

Specific proteolysis of the c-mos proto-oncogene product by calpain on fertilization of Xenopus eggs.

Watanabe N , Vande Woude GF , Ikawa Y , Sagata N .


Abstract
The Xenopus c-mos proto-oncogene product, pp39mos, accumulates in the unfertilized egg during maturation, is hyperphosphorylated and exhibits protein kinase activity. On fertilization, or soon after the completion of meiosis, the accumulated pp39mos undergoes selective proteolysis. Using an in vitro protease assay system, we show here that this specific proteolysis is caused by the calcium-dependent cysteine protease, calpain.

PubMed ID: 2555717
Article link: Nature


Species referenced: Xenopus laevis
Genes referenced: mos

References :
Hunt, Embryology. Under arrest in the cell cycle. 1990, Pubmed, Xenbase