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XB-ART-264
Int J Dev Biol January 1, 2006; 50 (6): 575-9.

Developmental expression of Shisa-2 in Xenopus laevis.

Silva AC , Filipe M , Vitorino M , Steinbeisser H , Belo JA .


Abstract
Shisa is an antagonist of Wnt and FGF signaling, that functions cell autonomously in the endoplasmic reticulum (ER) to inhibit the post-translational maturation of Wnt and FGF receptors. In this paper we report the isolation of a second Xenopus shisa gene (Xshisa-2). Xenopus Shisa-2 shows 30.7% identity to Xshisa. RT-PCR analysis indicated that Xshisa-2 mRNA is present throughout early development and shows an increased expression during neurula and tailbud stages. At neurula stages Xenopus shisa-2 is initially expressed in the presomitic paraxial mesoderm and later in the developing somites. The expression profiles and pattern of Xshisa and Xshisa-2 differ significantly. During gastrulation only Xshisa mRNA is present in the Spemann-Mangold organizer and later on becomes restricted to the neuroectoderm and the prechordal plate.

PubMed ID: 16741873
Article link: Int J Dev Biol


Species referenced: Xenopus laevis
Genes referenced: myod1 pcdh8 pcdh8.2 shisa1.1 shisa2


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