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XB-ART-26719
Proc Natl Acad Sci U S A 1989 Jun 01;8612:4554-8.
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Vgr-1, a mammalian gene related to Xenopus Vg-1, is a member of the transforming growth factor beta gene superfamily.

Lyons K , Graycar JL , Lee A , Hashmi S , Lindquist PB , Chen EY , Hogan BL , Derynck R .


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The transforming growth factor beta (TGF-beta)-related products of the Xenopus Vg-1 and Drosophila decapentaplegic (DPP) genes have been implicated in the control of growth and differentiation during embryogenesis. We have isolated a mouse cDNA, Vgr-1, that encodes a polypeptide structurally related to Xenopus Vg-1. Sequence comparisons indicate that the Vgr-1 protein belongs to a family of DPP-like gene products within the TGF-beta superfamily. The levels of Vgr-1 RNA were determined in embryos and tissues isolated at various stages of development. A 3.5-kilobase mRNA increases throughout development and into adulthood in many tissues and in F9 teratocarcinoma cells differentiating into endoderm in response to retinoic acid and cAMP. The amino acid homologies and patterns of expression suggest that, like the DPP gene product, Vgr-1 plays a role at various stages of development.

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Species referenced: Xenopus
Genes referenced: bmp6 camp dspp gdf1 tgfb1

References [+] :
Cate, Isolation of the bovine and human genes for Müllerian inhibiting substance and expression of the human gene in animal cells. 1986, Pubmed