Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
Science November 26, 2004; 306 (5701): 1571-3.

Nucleosome arrays reveal the two-start organization of the chromatin fiber.

Dorigo B , Schalch T , Kulangara A , Duda S , Schroeder RR , Richmond TJ .

Chromatin folding determines the accessibility of DNA constituting eukaryotic genomes and consequently is profoundly important in the mechanisms of nuclear processes such as gene regulation. Nucleosome arrays compact to form a 30-nanometer chromatin fiber of hitherto disputed structure. Two competing classes of models have been proposed in which nucleosomes are either arranged linearly in a one-start higher order helix or zigzag back and forth in a two-start helix. We analyzed compacted nucleosome arrays stabilized by introduction of disulfide cross-links and show that the chromatin fiber comprises two stacks of nucleosomes in accord with the two-start model.

PubMed ID: 15567867
Article link: Science

References :
Mohd-Sarip, Molecular biology. A higher order of silence. 2004, Pubmed