Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-ART-2674
Science November 26, 2004; 306 (5701): 1571-3.

Nucleosome arrays reveal the two-start organization of the chromatin fiber.

Dorigo B , Schalch T , Kulangara A , Duda S , Schroeder RR , Richmond TJ .


Abstract
Chromatin folding determines the accessibility of DNA constituting eukaryotic genomes and consequently is profoundly important in the mechanisms of nuclear processes such as gene regulation. Nucleosome arrays compact to form a 30-nanometer chromatin fiber of hitherto disputed structure. Two competing classes of models have been proposed in which nucleosomes are either arranged linearly in a one-start higher order helix or zigzag back and forth in a two-start helix. We analyzed compacted nucleosome arrays stabilized by introduction of disulfide cross-links and show that the chromatin fiber comprises two stacks of nucleosomes in accord with the two-start model.

PubMed ID: 15567867
Article link: Science



References :
Mohd-Sarip, Molecular biology. A higher order of silence. 2004, Pubmed