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Nature May 25, 1989; 339 (6222): 275-80.

Cyclin synthesis drives the early embryonic cell cycle.

Murray AW , Kirschner MW .

We have produced extracts of frog eggs that can perform multiple cell cycles in vitro. Destruction of the endogenous messenger RNA arrests the extracts in interphase. The addition of exogenous cyclin mRNA is sufficient to produce multiple cell cycles. The newly synthesized cyclin protein accumulates during each interphase and is degraded at the end of each mitosis.

PubMed ID: 2566917
Article link: Nature