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Dev Biol April 1, 1989; 132 (2): 529-43.

Amphibian (urodele) myotomes display transitory anterior/posterior and medial/lateral differentiation patterns.

Neff AW , Malacinski GM , Chung HM .

Myotome differentiation during Mexican axolotl (Ambystoma mexicanum) somitogenesis was analyzed by employing anti-actin and anti-myosin monoclonal antibodies as molecular probes. Myotome differentiation occurs after segmentation and proceeds in the cranial-to-caudal direction along the somite file. Within individual somites myotome differentiation displays distinct polarities. Examination of the somite file at the tailbud stage revealed that soon after segmentation, actin/myosin accumulate predominantly in the anterior and medial region of the myotome initially. Subsequently, cells within the myotome differentiate in an anterior-to-posterior and medial-to-lateral direction. Experimental analysis of presomitic paraxial mesoderm grafts before segmentation revealed that this transient myotome polarity is autonomous. Comparative analyses indicate that this myotome differentiation pattern is urodele specific. Cynops pyrrhogaster undergoes myotome differentiation like the axolotl, while two anurans, Xenopus laevis and Bombina orientalis, do not.

PubMed ID: 2647546
Article link: Dev Biol
Grant support: [+]

Species referenced: Xenopus laevis
Genes referenced: acta4 actl6a elavl3
Antibodies: Act3 Ab2 Somite Ab1

Article Images: [+] show captions