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XB-ART-26968
Nucleic Acids Res January 11, 1989; 17 (1): 11-8.

Isolation of the Xenopus homolog of int-1/wingless and expression during neurula stages of early development.

Noordermeer J , Meijlink F , Verrijzer P , Rijsewijk F , Destrée O .


Abstract
We have isolated the Xenopus homolog (Xint-1) of the mouse protooncogene int-1 from a neurula stage 17 cDNA library. The deduced protein sequence of Xint-1 includes 371 amino acids. The Xint-1 protein is more similar to the mammalian int-1 product (69%), than to the Drosophila counterpart of int-1, wingless (50%). Xint-1 shares several characteristics of secreted proteins with the other int-1 homologs: it has a hydrophobic leader, multiple conserved potential N-linked glycosylation sites and is rich in cysteine residues. All 23 cysteines are conserved in the three proteins. Xint-1 is transiently expressed during the neurula stages of early Xenopus development.

PubMed ID: 2911462
PMC ID: PMC331531
Article link: Nucleic Acids Res


Species referenced: Xenopus
Genes referenced: intu wnt1

References [+] :
Baker, Molecular cloning of sequences from wingless, a segment polarity gene in Drosophila: the spatial distribution of a transcript in embryos. 2010, Pubmed