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XB-ART-2702
Int J Dev Biol January 1, 2004; 48 (8-9): 761-70.

Regulation of vertebrate eye development by Rx genes.

Bailey TJ , El-Hodiri H , Zhang L , Shah R , Mathers PH , Jamrich M .


Abstract
The paired-like homeobox-containing gene Rx has a critical role in the eye development of several vertebrate species including Xenopus, mouse, chicken, medaka, zebrafish and human. Rx is initially expressed in the anterior neural region of developing embryos, and later in the retina and ventral hypothalamus. Abnormal regulation or function of Rx results in severe abnormalities of eye formation. Overexpression of Rx in Xenopus and zebrafish embryos leads to overproliferation of retinal cells. A targeted elimination of Rx in mice results in a lack of eye formation. Mutations in Rx genes are the cause of the mouse mutation eyeless (ey1), the medaka temperature sensitive mutation eyeless (el) and the zebrafish mutation chokh. In humans, mutations in Rx lead to anophthalmia. All of these studies indicate that Rx genes are key factors in vertebrate eye formation. Because these results cannot be easily reconciled with the most popular dogmas of the field, we offer our interpretation of eye development and evolution.

PubMed ID: 15558469
Article link: Int J Dev Biol
Grant support: [+]

Species referenced: Xenopus
Genes referenced: bmp4 cdknx cer1 chrd.1 foxg1 frs2 fst hes1 lhx2 mab21l2 neurog2 nodal nodal1 nog otx2 pax6 rax rpe six3 six6 tbx2 wnt1 zic2


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