Nature. October 6, 1988; 335 (6190):
Function of c-mos proto-oncogene product in meiotic maturation in Xenopus oocytes.
Sagata N , Oskarsson M , Copeland T , Brumbaugh J , Vande Woude GF .
AbstractThe c-mos proto-oncogene is expressed as a maternal mRNA in oocytes and early embryos of Xenopus laevis, but its translation product pp39mos is detectable only during progesterone-induced oocyte maturation. Microinjection of mos-specific antisense oligonucleotides into oocytes not only prevents expression of pp39mos, but also blocks germinal vesicle breakdown, indicating that it functions during reinitiation of meiotic division.
Pubmed Id: 2971141Article link: Nature.
Genes referenced: mos