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XB-ART-27253
Nature. October 6, 1988; 335 (6190): Function of c-mos proto-oncogene product in meiotic maturation in Xenopus oocytes.
Sagata N
,
Oskarsson M
,
Copeland T
,
Brumbaugh J
,
Vande Woude GF
.
Abstract The c-mos proto-oncogene is expressed as a maternal mRNA in oocytes and early embryos of Xenopus laevis, but its translation product pp39mos is detectable only during progesterone-induced oocyte maturation. Microinjection of mos-specific antisense oligonucleotides into oocytes not only prevents expression of pp39mos, but also blocks germinal vesicle breakdown, indicating that it functions during reinitiation of meiotic division.Pubmed Id: 2971141 Article link: Nature.Genes referenced: mos Antibodies referenced: |
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