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XB-ART-27253
Nature October 6, 1988; 335 (6190): 519-25.

Function of c-mos proto-oncogene product in meiotic maturation in Xenopus oocytes.

Sagata N , Oskarsson M , Copeland T , Brumbaugh J , Vande Woude GF .


Abstract
The c-mos proto-oncogene is expressed as a maternal mRNA in oocytes and early embryos of Xenopus laevis, but its translation product pp39mos is detectable only during progesterone-induced oocyte maturation. Microinjection of mos-specific antisense oligonucleotides into oocytes not only prevents expression of pp39mos, but also blocks germinal vesicle breakdown, indicating that it functions during reinitiation of meiotic division.

PubMed ID: 2971141
Article link: Nature

Genes referenced: mos



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