Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-ART-27379
Dev Biol 1988 Aug 01;4641:75-9.
Show Gene links Show Anatomy links

Functional expression of brain cholecystokinin and bombesin receptors in Xenopus oocytes.

Moriarty TM , Gillo B , Sealfon S , Roberts JL , Blitzer RD , Landau EM .


???displayArticle.abstract???
Total RNA was extracted from 15-day-old whole rat brains. Microinjection of the RNA into Xenopus laevis oocytes induced electrophysiological responsiveness to cholecystokinin-8 (CCK) and bombesin (BBS) but not to corticotropin-releasing factor (CRF) or somatostatin. The responses to CCK and BBS were similar in shape, time course, and reversal potential to that induced by receptor mediated phospholipid breakdown and that which is induced by intracellular injection of IP3. These responses were not blocked by atropine or by mianserin, did not require extracellular Ca2+ and were completely suppressed by intracellular injection of EGTA.

???displayArticle.pubmedLink??? 2902910

???displayArticle.grants??? [+]

Species referenced: Xenopus laevis
Genes referenced: cck crh grp pomc sst.1