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XB-ART-2742
Nat Cell Biol December 1, 2004; 6 (12): 1212-20.

Non-canonical Wnt signals are modulated by the Kaiso transcriptional repressor and p120-catenin.

Kim SW , Park JI , Spring CM , Sater AK , Ji H , Otchere AA , Daniel JM , McCrea PD .


Abstract
Gastrulation movements are critical for establishing the three principal germ layers and the basic architecture of vertebrate embryos. Although the individual molecules and pathways involved are not clearly understood, non-canonical Wnt signals are known to participate in developmental processes, including planar cell polarity and directed cell rearrangements. Here we demonstrate that the dual-specificity transcriptional repressor Kaiso, first identified in association with p120-catenin, is required for Xenopus gastrulation movements. In addition, depletion of xKaiso results in increased expression of the non-canonical xWnt11, which contributes to the xKaiso knockdown phenotype as it is significantly rescued by dominant-negative Wnt11. We further demonstrate that xWnt11 is a direct gene target of xKaiso and that p120-catenin association relieves xKaiso repression in vivo. Our results indicate that p120-catenin and Kaiso are essential components of a new developmental gene regulatory pathway that controls vertebrate morphogenesis.

PubMed ID: 15543138
Article link: Nat Cell Biol
Grant support: [+]
Genes referenced: ctnnd1 sult4a1 wnt11 wnt11b zbtb33
Morpholinos: sult4a1 MO1 zbtb33 MO1



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