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Nucleic Acids Res February 25, 1988; 16 (4): 1453-69.

Xenopus homeobox-containing cDNAs expressed in early development.

We report the isolation of six different homeobox-containing genes in Xenopus laevis which are expressed during early embryogenesis. cDNA clones of all of them were partially sequenced including two from previously isolated Xenopus genomic loci and found to contain homeodomains which share a high degree of homology with the Antennapedia protein (50 to 59 out of 60 amino acids). We find a short region of homology (consensus Ile Tyr Pro Trp Met) in four of the cDNAs, which is also present in Antennapedia and that may correspond to a bend region preceding the homeodomain. Northern blots have been performed to show the transcriptional pattern through early frog embryogenesis. Three of the genes are expressed only during a very narrow period of embryogenesis, reinforcing the view that homeobox genes are developmentally regulated.

PubMed ID: 2894634
PMC ID: PMC336327
Article link: Nucleic Acids Res
Grant support: [+]

Species referenced: Xenopus
Genes referenced: actl6a hoxa7 hoxb5 hoxb7 hoxc6 ncoa6

Article Images: [+] show captions
References [+] :
Akam, The molecular basis for metameric pattern in the Drosophila embryo. 1988, Pubmed