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XB-ART-27736
Acta Biol Hung 1988 Jan 01;392-3:201-9.
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A glial cell line promotes the outgrowth of neurites from embryonic Xenopus retina.

Sakaguchi DS , Coffman CR , Gallenson N , Harris WA .


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A glial cell line (XR1 cell line) derived from Xenopus retinal neuroepithelium was examined for neurite outgrowth promoting activity. A monolayer of the XR1 cells serves as an excellent substrate upon which embryonic retinal explants attach and freely elaborate neurites. The XR1 neurite outgrowth promoting activity is not secreted into the medium, but is laid down directly on the substrate where it remains active after lysing the cells by hypoosmotic shock. A polyclonal antiserum raised against membranes of the XR1 cells was effective in blocking neurite outgrowth on XR1 conditioned collagen. It is proposed that the neurite outgrowth promoting factors produced by the XR1 cells are associated with the extracellular matrix and possibly glial specific.

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