Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-ART-28981
Cell 1985 Dec 01;433 Pt 2:615-21.
Show Gene links Show Anatomy links

ras proteins can induce meiosis in Xenopus oocytes.

Birchmeier C , Broek D , Wigler M .


???displayArticle.abstract???
Injection of human H-ras protein induces maturation of Xenopus oocytes; that is, progression from prophase to metaphase of meiosis. The oncogenic protein encoded by H-rasval12 is nearly a 100-fold more potent than the protein encoded by the wild-type gene. We do not observe any measurable increase or decrease in cyclic AMP concentration in injected oocytes, and the effects of H-ras protein are only partially blocked by cholera toxin. Our results suggest that not all, if any, of the effects of H-rasval12 protein in this system are mediated by adenylate cyclase.

???displayArticle.pubmedLink??? 2416466
???displayArticle.link??? Cell
???displayArticle.grants??? [+]

Species referenced: Xenopus laevis
Genes referenced: hras