Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-ART-29004
J Embryol Exp Morphol November 1, 1985; 89 Suppl 317-31.

Cell lineage labels and region-specific markers in the analysis of inductive interactions.



Abstract
This paper reviews work with cell lineage labels and cell-type specific markers in the analysis of inductive interactions in early amphibian development. Our results provide clear evidence for the existence of three such interactions. Mesodermal induction occurs in the early blastula and results from the action of vegetal pole cells on the animal hemisphere. At least two mesodermal rudiments are formed, one dorsal and one ventral. During the next interaction, which we call dorsalization, the ventral mesodermal rudiment becomes subdivided into several territories under the influence of the dorsal marginal zone, or organizer. Finally, during gastrulation, the involuting organizer induces neural tissue from the overlying ectoderm. This interaction is called neural induction. Although these phenomena can readily be demonstrated under experimental conditions, direct evidence that they occur in normal development awaits an understanding of the molecular basis of induction.

PubMed ID: 3831217
Article link: J Embryol Exp Morphol



Xenbase: The Xenopus Model Organism Knowledgebase.
Version: 4.15.0
Major funding for Xenbase is provided by grant P41 HD064556