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Nature February 16, 1984; 307 (5952): 604-8.

Expression of functional acetylcholine receptor from cloned cDNAs.

Mishina M , Kurosaki T , Tobimatsu T , Morimoto Y , Noda M , Yamamoto T , Terao M , Lindstrom J , Takahashi T , Kuno M .

The cloned cDNAs encoding the four subunits of the Torpedo californica acetylcholine receptor, each carried by a simian virus 40 vector, direct the synthesis of the functional receptor in a combined expression system consisting of COS monkey cells and Xenopus oocytes. Our results suggest that all four subunits are required to elicit a normal nicotinic response to acetylcholine, whereas only the alpha-subunit is indispensable for alpha-bungarotoxin binding activity.

PubMed ID: 6320016
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