Dev Biol 1983 Oct 01;992:524-8.

Developmental change of a depolarization-induced sodium permeability in the oocyte of Xenopus laevis.

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In the full grown oocyte of Xenopus laevis, a sodium permeability can be induced by depolarization to positive potential with current injection. Voltage-clamp analysis has shown that depolarization causes a long-lasting modification of the membrane during which voltage-gated sodium channels become functional. In the present study, I have looked for the existence of these channels during cell growth. The channels appear during a very restricted period of cell growth, corresponding to Dumont stage V. A possible biological function is discussed.

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