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XB-ART-30169
J Cell Biol July 1, 1983; 97 (1): 217-23.

Cytoskeletal components of the vertebrate neuromuscular junction: vinculin, alpha-actinin, and filamin.

Bloch RJ , Hall ZW .


Abstract
We have used immunocytochemical methods to investigate the cytoskeletal constituents of the vertebrate neuromuscular junction. Specific, affinity-purified antibodies to three cytoskeletal proteins, vinculin, alpha-actinin, and filamin, bound to neuromuscular junctions in sections of normal rat, mouse, chick, and Xenopus muscles. All three antibodies bound to the synaptic regions of denervated rat muscle fibers, indicating that the proteins recognized by these antibodies are associated with postsynaptic structures. The three proteins are present at the neuromuscular junction in muscle fibers of embryonic and neonatal animals, and therefore, may play an important role in its differentiation.

PubMed ID: 6408100
PMC ID: PMC2112479
Article link:


Species referenced: Xenopus laevis
Genes referenced: actn1 avd flnb ttl vcl


Article Images: [+] show captions
References [+] :
Bader, Density and distribution of alpha-bungarotoxin-binding sites in postsynaptic structures of regenerated rat skeletal muscle. 1981, Pubmed