Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
Cyclic AMP-mediated control of meiosis: effects of progesterone, cholera toxin, and membrane-active drugs in Xenopus laevis oocytes.
Schorderet-Slatkine S
,
Schorderet M
,
Baulieu EE
.
???displayArticle.abstract???
Progesterone depressed rapidly (50% at 1 min) and persistently cyclic AMP (cAMP) concentration that had been elevated by cholera toxin in Xenopus laevis oocytes. cAMP remained below 1 pmol per oocyte (mean basal level) for approximately 1 hr and thereafter rose to approximately 120% of control values, while germinal vesicle (nucleus) breakdown did not occur. In the absence of cholera toxin, progesterone treatment for 6 hr maintained cAMP concentration below the basal level (but not lower than 80%), and germinal vesicle breakdown occurred. Experiments in the presence of phosphodiesterase inhibitors suggested that progesterone modulates adenylate cyclase activity. The maturation promoting factor, which is formed after 3-5 hr of progesterone treatment and provokes germinal vesicle breakdown after its injection into untreated oocytes, also decreased cAMP concentration, an observation that may explain its "autoamplification." Nonsteroidal inducers of meiosis reinitiation (e.g., propranolol, methoxyverapamil, mersalyl) diminished the cholera toxin-mediated accumulation of cAMP, in contrast to compounds devoid of meiotic-inducing capacity and antagonist to progesterone action, such as gammexane (an inositol analogue) and 5'-deoxy-S-(2-methylpropyl)-5'-thioadenosine (a methylase inhibitor), that increased the nucleotide level. The fine control, suggested by the effects of small changes in cAMP levels, gives evidence of great sensitivity to a critical determinant governing meiotic cell division.
Allende,
Comparison of in vivo and in vitro properties of cyclic adenosine 3':5'-monophosphate phosphodiesterase of amphibian oocytes.
1977, Pubmed,
Xenbase
Allende,
Comparison of in vivo and in vitro properties of cyclic adenosine 3':5'-monophosphate phosphodiesterase of amphibian oocytes.
1977,
Pubmed
,
Xenbase
Balakier,
Cytoplasmic control of nuclear maturation in mouse oocytes.
1977,
Pubmed
Baulieu,
Steroid-induced meiotic division in Xenopus laevis oocytes: surface and calcium.
1978,
Pubmed
,
Xenbase
Berridge,
The interaction of cyclic nucleotides and calcium in the control of cellular activity.
1975,
Pubmed
Bourne,
Genetic analysis of cyclic AMP in a mammalian cell.
1975,
Pubmed
Brachet,
Induction of maturation (meiosis) in Xenopus laevis oocytes by three organomercurials.
1975,
Pubmed
,
Xenbase
Bravo,
Amphibian oocyte maturation and protein synthesis: related inhibition by cyclic AMP, theophylline, and papaverine.
1978,
Pubmed
,
Xenbase
Cho,
Inhibitory effect of dibutyryl cAMP on mouse oocyte maturation in vitro.
1974,
Pubmed
Davies,
The influence of propranolol on the thyrotropin receptor.
1977,
Pubmed
Drury,
Effects of cycloheximide on the "autocatalytic" nature of the maturation promoting factor (MPF) in oocytes of Xenopus laevis.
1975,
Pubmed
,
Xenbase
El-Etr,
Meiotic maturation in Xenopus laevis oocytes initiated by insulin.
1979,
Pubmed
,
Xenbase
Enouf,
Relationship between inhibition of protein methylase I and inhibition of Rous sarcoma virus-induced cell transformation.
1979,
Pubmed
Finidori-Lepicard,
Progesterone inhibits membrane-bound adenylate cyclase in Xenopus laevis oocytes.
1981,
Pubmed
,
Xenbase
Godeau,
[Inhibition by the enterotoxin of Vibrio cholerase of meiosis reinitiation of the Xenopus laevis oocyte induced in vitro by progesterone].
1978,
Pubmed
,
Xenbase
Hancock,
Verapamil-induced changes in myocardial contractile force and cyclic nucleotides in the isolated perfused rat heart.
1979,
Pubmed
Hepp,
Inhibition of catecholamine-stimulated adenylate cyclase in fat cells by local anaesthetics.
1978,
Pubmed
Hirata,
Phospholipid methylation and biological signal transmission.
1980,
Pubmed
Lambert,
Inhibition by insulin of the adrenaline-stimulated adenylate cyclase in rat adipose tissue.
1979,
Pubmed
Maller,
Progesterone-stimulated meiotic cell division in Xenopus oocytes. Induction by regulatory subunit and inhibition by catalytic subunit of adenosine 3':5'-monophosphate-dependent protein kinase.
1977,
Pubmed
,
Xenbase
Maller,
Early effect of progesterone on levels of cyclic adenosine 3':5'-monophosphate in Xenopus oocytes.
1979,
Pubmed
,
Xenbase
Masui,
Cytoplasmic control of nuclear behavior during meiotic maturation of frog oocytes.
1971,
Pubmed
Masui,
Oocyte maturation.
1979,
Pubmed
Mavier,
Adenylate cyclase from rat-liver plasma membrane: inhibition by mersalyl and other mercurial derivatives.
1975,
Pubmed
Michell,
Inositol phospholipids and cell surface receptor function.
1975,
Pubmed
Moreau,
Free calcium changes associated with hormone action in amphibian oocytes.
1980,
Pubmed
,
Xenbase
Morrill,
Changes in cyclic AMP levels in the amphibian ovarian follicle following progesterone induction of meiotic maturation. Effect of phosphodiesterase inhibitors and exogenous calcium on germinal vesicle breakdown.
1977,
Pubmed
Mulner,
Cyclic AMP synthesis in Xenopus laevis oocytes: inhibition by progesterone.
1979,
Pubmed
,
Xenbase
Mulner,
Cyclic AMP phosphodiesterase activities in Xenopus laevis oocytes.
1980,
Pubmed
,
Xenbase
Nathanson,
Lanthanum inhibits brain adenylate cyclase and blocks noradrenergic depression of Purkinje cell discharge independent of calcium.
1976,
Pubmed
O'Connor,
Inhibition of oocyte maturation by theophylline: possible mechanism of action.
1976,
Pubmed
,
Xenbase
Pastan,
Role of cyclic nucleotides in growth control.
1975,
Pubmed
Reynhout,
Studies on the appearance and nature of a maturation-inducing factor in the cytoplasm of amphibian oocytes exposed to progesterone.
1974,
Pubmed
,
Xenbase
Sadler,
Progesterone inhibits adenylate cyclase in Xenopus oocytes. Action on the guanine nucleotide regulatory protein.
1981,
Pubmed
,
Xenbase
Schorderet-Slatkine,
Progesterone induced maturation in oocytes of Xenopus laevis. Appearance of a 'maturation promoting factor' in enucleated oocytes.
1973,
Pubmed
,
Xenbase
Schorderet-Slatkine,
Inhibition of the progesterone-dependent induction of meiosis by gammexane in Xenopus laevis oocytes.
1977,
Pubmed
,
Xenbase
Schorderet-Slatkine,
Progesterone-induced meiotic reinitation in vitro in Xenopus laevis oocytes: a role for the displacement of membrane-bound calcium.
1977,
Pubmed
,
Xenbase
Schorderet-Slatkine,
Progesterone-induced meiosis in Xenopus laevis oocytes: a role for cAMP at the "maturation-promoting factor" level.
1978,
Pubmed
,
Xenbase
Schorderet-Slatkine,
Effect of a methyl-transferase inhibitor, 5'-deoxy'5'-S-isobutyl-thioadenosine (SIBA) on cAMP level and progesterone induced meiosis reinitiation in Xenopus laevis oocytes.
1981,
Pubmed
,
Xenbase
Schutter,
Cyclic nucleotides and amphibian development.
1975,
Pubmed
,
Xenbase
Speaker,
Cyclic nucleotide fluctuations during steroid induced meiotic maturation of frog oocytes.
1977,
Pubmed
Sunkara,
Mitotic factors from mammalian cells induce germinal vesicle breakdown and chromosome condensation in amphibian oocytes.
1979,
Pubmed
,
Xenbase
Warren,
Cholesterol is excluded from the phospholipid annulus surrounding an active calcium transport protein.
1975,
Pubmed
Wasserman,
Progesterone induces a rapid increase in [Ca2+]in of Xenopus laevis oocytes.
1980,
Pubmed
,
Xenbase
