Differentiation 1980 Feb 01;161:1-7. doi: 10.1111/j.1432-0436.1980.tb01052.x.

Active suppression of the allogeneic histocompatibility reactions during the metamorphosis of the clawed toad Xenopus.

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Metamorphosis is a privileged period for the induction of tolerance to allografts. Transfer of lymphocytes from metamorphosing Xenopus into isogenic adults prevented the rejection of a skin graft differing from the adult host by minor histocompatibility antigens. This implies that active suppression is involved at one step of the induction of tolerance to the self-antigens that differentiate at the time of metamorphosis. The reciprocal experiments of preventing tolerance induction by transfer of normal adult cells into metamorphosing animals failed. However, passive transfer of anti-graft immunity in tolerant animals was partially observed, provided that a transfer of primed cells was done simultaneously with the challenging graft. Thus, memory cells are not as sensitive to the suppression as are the cells that respond in a first set reaction.

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