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Cell Tissue Res January 1, 1980; 211 (2): 241-50.

Substance P-related peptides in the hypothalamus of amphibia.

Gaudino G , Fasolo A .

The occurrence of Substance P-(SP)-related peptides in the hypothalamus of three species of Amphibia (newt, clawed, toad, frog) was studied immunohistochemically employing the direct immunofluorescence method or a double-step technique (indirect immunofluorescence followed by the peroxidase-antiperoxidase complex method). SP-like immunopositive fibers are seen throughout the hypothalamus. They are especially abundant in the preoptic area and in the outer zone of the median eminence, suggesting a role of SP-related peptides in the hypothalamo-hypophysial regulation in these animals. Some SP-like neurons are seen in the posterior hypothalamus and in the preoptic area. In the newt, such SP-like immunopositive neurons occur frequently in the preoptic periventricular grey.

PubMed ID: 6158373
Article link:

Species referenced: Xenopus
Genes referenced: tac1

References [+] :
Alpert, Localization of LHRH in neurons in frog brain (Rana pipiens and Rana catesbeiana). 1976, Pubmed