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EMBO J August 18, 2004; 23 (16): 3259-69.

Paraxial protocadherin coordinates cell polarity during convergent extension via Rho A and JNK.

Unterseher F , Hefele JA , Giehl K , De Robertis EM , Wedlich D , Schambony A .

Convergent extension movements occur ubiquitously in animal development. This special type of cell movement is controlled by the Wnt/planar cell polarity (PCP) pathway. Here we show that Xenopus paraxial protocadherin (XPAPC) functionally interacts with the Wnt/PCP pathway in the control of convergence and extension (CE) movements in Xenopus laevis. XPAPC functions as a signalling molecule that coordinates cell polarity of the involuting mesoderm in mediolateral orientation and thus selectively promotes convergence in CE movements. XPAPC signals through the small GTPases Rho A and Rac 1 and c-jun N-terminal kinase (JNK). Loss of XPAPC function blocks Rho A-mediated JNK activation. Despite common downstream components, XPAPC and Wnt/PCP signalling are not redundant, and the activity of both, XPAPC and PCP signalling, is required to coordinate CE movements.

PubMed ID: 15297873
PMC ID: PMC514506
Article link: EMBO J

Genes referenced: akt1 fzd7 jun mapk8 pcdh8 pcdh8.2 rac1 rho rho.2
Morpholinos: fzd7 MO1 pcdh8.2 MO1 pcdh8.2 MO2

References [+] :
Agius, Endodermal Nodal-related signals and mesoderm induction in Xenopus. 2000, Pubmed, Xenbase

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