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Synthesis of human interferon by Xenopus laevis oocytes: two structural genes for interferons in human cells.
Cavalieri RL
,
Havell EA
,
Vilcek J
,
Pestka S
.
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Human fibroblasts and leukocytes produce interferons which may be distinguished by their antigenic and species specificity as well as by their molecular weight distributions. To elucidate the basis for these differences, we isolated mRNA from induced human fibroblasts and lymphoblastoid (Namalva) cells and studied the products of translation in Xenopus laevis oocytes. The mRNA from the respective cells yielded translation products, in oocytes, that were characteristic of the cells from which the mRNA was derived. We conclude that human cells contain at least two structural genes for interferon, coding for polypeptides differing in primary sequence. Fibroblasts synthesize a single species of interferon; lymphoblastoid cells synthesize two species, the fibroblast and leukocyte types.
Berg,
Affinity chromatography of human leukocyte and diploid cell interferons on sepharose-bound antibodies.
1975, Pubmed
Berg,
Affinity chromatography of human leukocyte and diploid cell interferons on sepharose-bound antibodies.
1975,
Pubmed
Berggård,
Isolation and properties of a low molecular weight beta-2-globulin occurring in human biological fluids.
1968,
Pubmed
Berns,
Calf crystallin synthesis in frog cells: the translation of lens-cell 14S RNA in oocytes.
1972,
Pubmed
,
Xenbase
Bose,
Apparent dispensability of the carbohydrate moiety of human interferon for antiviral activity.
1976,
Pubmed
Colby,
Interferon induction and action.
1971,
Pubmed
Dugan,
Amino acid sequence of the light chain of a mouse myeloma protein (MOPC-315).
1973,
Pubmed
Green,
Cell-free translation of immunoglobulin messenger RNA from MOPC-315 plasmacytoma and MOPC-315 NR, a variant synthesizing only light chain.
1975,
Pubmed
Green,
Isolation and cell-free translation of immunoglobulin messenger RNA.
1976,
Pubmed
Gresser,
Pronounced antiviral activity of human interferon on bovine and porcine cells.
1974,
Pubmed
Gurdon,
Use of frog eggs and oocytes for the study of messenger RNA and its translation in living cells.
1971,
Pubmed
,
Xenbase
Havell,
Two antigenically distinct species of human interferon.
1975,
Pubmed
Havell,
Suppression of human interferon production by inhibitors of glycosylation.
1975,
Pubmed
Ho,
Interferon.
1975,
Pubmed
Jankowski,
Molecular structure of human fibroblast and leukocyte interferons: probe by lectin and hydrophobic chromatography.
1975,
Pubmed
Klein,
Sensitivity of Epstein-Barr virus (EBV) producer and non-producer human lymphoblastoid cell lines to superinfection with EB-virus.
1972,
Pubmed
Knight,
Interferon: purification and initial characterization from human diploid cells.
1976,
Pubmed
Kronenberg,
Relative quantitative assay of the biological activity of interferon messenger ribonucleic acid.
1975,
Pubmed
Laemmli,
Cleavage of structural proteins during the assembly of the head of bacteriophage T4.
1970,
Pubmed
Laskey,
Translation of encephalomyocarditis viral RNA in oocytes of Xenopus laevis.
1972,
Pubmed
,
Xenbase
Mach,
Purification of 14S messenger RNA of immunoglobulin light chain that codes for a possible light-chain precursor.
1973,
Pubmed
Moar,
Translational capacity of living frog eggs and oocytes, as judged by messenger RNA injection.
1971,
Pubmed
Pestka,
Studies on the formation of ribonucleic acid-ribosome complexes. XVI. Effect of ribosomal translocation inhibitors on polyribosomes.
1971,
Pubmed
Pestka,
Cell-free synthesis of human interferon.
1975,
Pubmed
Reynolds,
The induction of interferon and its messenger RNA in human fibroblasts.
1974,
Pubmed
Reynolds,
Interferon activity produced by translation of human interferon messenger RNA in cell-free ribosomal systems and in Xenopus oöcytes.
1975,
Pubmed
,
Xenbase
Stewart,
Molecular heterogeneity of human leukocyte interferon: two populations differing in molecular weights, requirements for renaturation, and cross-species antiviral activity.
1975,
Pubmed
Stewart,
Identification of the cell multiplication inhibitory factors in interferon preparations as interferons.
1976,
Pubmed
Strander,
Production of human lymphoblastoid interferon.
1975,
Pubmed
Tan,
Human chromosome 21 dosage: effect on the expression of the interferon induced antiviral state.
1974,
Pubmed
Thang,
Biosynthesis of mouse interferon by translation of its messenger RNA in a cell-free system.
1975,
Pubmed
Tucker,
De novo synthesis and glycosylation of the MOPC-46B mouse immunoglobulin light chain in cell-free extracts.
1977,
Pubmed
Underdown,
Subunit structure and number of combining sites of the immunoglobulin A myeloma protein produced by mouse plasmacytoma MOPC-315.
1971,
Pubmed
Vilcek,
Antigenic, physicochemical, and biologic characterization of human interferons.
1977,
Pubmed
de Maeyer-Guignard,
Interferon messenger RNA: translation in heterologous cells.
1972,
Pubmed
