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XB-ART-32200
Proc Natl Acad Sci U S A August 1, 1977; 74 (8): 3230-4.

Frog oocytes synthesize and completely process the precursor polypeptide to virion structural proteins after microinjection of avian myeloblastosis virus RNA.

Ghysdael J , Hubert E , Trávnícek M , Bolognesi DP , Burny A , Cleuter Y , Huez G , Kettmann R , Marbaix G , Portetelle D , Chantrenne H .


Abstract
After microinjection of Xenopus laevis oocytes with RNA from avian myeloblastosis virus, viral structural proteins p27, p19, p15, and p12 are formed by a sequence of posttranslational cleavages of a high-molecular-weight precursor polypeptide. The 60-70S RNA aggregate or its 30-40S RNA subunits obtained by heat or formamide treatment possess the same ability to serve as template in X. laevis oocytes. The processing pattern of virus-specific precursor polypeptides is the same in X. laevis oocytes as in chick embryo fibroblasts infected with avian myeloblastosis virus, but the processing takes place at a much slower rate.

PubMed ID: 198776
PMC ID: PMC431509
Article link:


Species referenced: Xenopus
Genes referenced: cdkn2b znrd2

References [+] :
August, A proposed nomenclature for the virion proteins of oncogenic RNA viruses. 1974, Pubmed