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Proc Natl Acad Sci U S A
1971 Nov 01;6811:2769-73.
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Synthesis of amplified DNA that codes for ribosomal RNA.
Crippa M
,
Tocchini-Valentini GP
.
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During the amplification stage in ovaries, the complete repetitive unit of the DNA that codes for ribosomal RNA in Xenopus appears to be transcribed. This large RNA transcript is found in a complex with DNA. Substitution experiments with 5-bromodeoxyuridine do not show any evidence that a complete amplified cistron is used as a template for further amplification. A derivative of rifampicin, 2',5'-dimethyl-N(4')benzyl-N(4')[desmethyl] rifampicin, preferentially inhibits the DNA synthesis responsible for ribosomal gene amplification. These results are consistent with the hypothesis that RNA-dependent DNA synthesis is involved in gene amplification.
BROWN,
VARIATIONS IN THE SYNTHESIS OF STABLE RNA'S DURING OOGENESIS AND DEVELOPMENT OF XENOPUS LAEVIS.
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BROWN,
VARIATIONS IN THE SYNTHESIS OF STABLE RNA'S DURING OOGENESIS AND DEVELOPMENT OF XENOPUS LAEVIS.
1964,
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Baltimore,
RNA-dependent DNA polymerase in virions of RNA tumour viruses.
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Properties and composition of the isolated ribosomal DNA satellite of Xenopus laevis.
1968,
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Birnstiel,
The ribosomal RNA cistrons.
1971,
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Brown,
Specific gene amplification in oocytes. Oocyte nuclei contain extrachromosomal replicas of the genes for ribosomal RNA.
1968,
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Gene linkage by RNA-DNA hybridization. II. Arrangement of the redundant gene sequences for 28 s and 18 s ribosomal RNA.
1968,
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Dawid,
Composition and structure of chromosomal and amplified ribosomal DNA's of Xenopus laevis.
1970,
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Evans,
Localization of amplified ribosomal DNA in the oocyte of Xenopus laevis.
1968,
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Gall,
Differential synthesis of the genes for ribosomal RNA during amphibian oögenesis.
1968,
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The genes for ribosomal RNA during oögenesis.
1969,
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Gillespie,
A quantitative assay for DNA-RNA hybrids with DNA immobilized on a membrane.
1965,
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Gurdon,
The replication of purified DNA introduced into living egg cytoplasm.
1969,
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Gurgo,
Inhibitors of the RNA and DNA dependent polymerase activities of RNA tumour viruses.
1971,
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Landesman,
Patterns of macromolecule synthesis during development of Xenopus laevis. II. Identification of the 40 S precursor to ribosomal RNA.
1969,
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Loening,
Properties of the ribosomal RNA precursor in Xenopus laevis; comparison to the precursor in mammals and in plants.
1969,
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Mairy,
[Biochemical studies on oogenesis. I. RNA synthesis and accumulation during oogenesis of the South African toad Xenopus laevis].
1971,
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Temin,
RNA-dependent DNA polymerase in virions of Rous sarcoma virus.
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Ribonucleic acids and ribonucleoproteins from small oöcytes of Xenopus laevis.
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