XB-ART-34314Semin Cell Dev Biol. April 1, 2006; 17 (2): 214-22.
Apical-basal polarity, Wnt signaling and vertebrate organogenesis.
Wnt proteins elicit several distinct signal transduction cascades and regulate multiple cellular processes that have proven essential for embryonic development in all metazoans investigated. During embryonic development, epithelial cells become polarized along two axes: apical/basal and within the plane of the tissue. Growing evidence suggests that polarization along each axis is essential for normal embryonic development and that this polarization is regulated in part by the different branches of the Wnt pathway. Here, we review the role of A/B cell polarity in vertebrate organogenesis with a focus on the involvement of canonical Wnt signaling in this process.
PubMed ID: 16839789
Article link: Semin Cell Dev Biol.
Genes referenced: cdc42 dvl2 f2r mapk8 prkci rho rhou
Article Images: [+] show captions
|Fig. 2. Molecular control of epithelial organization. (A) Epithelial cells are divided into three domains: apical, lateral and basal. The junctional complexes separate the apical from the lateral domains. (B) Several protein complexes interact to organize the epithelial cell including the apical crumbs complex (purple), the junctional Par complex (red) and the basolateral scribble complex (yellow). See text for details.|
|Fig. 3. The role of aPKC in organogenesis. has and nok mutants lack polarity and are defective in lateral plate mesoderm migration. (A and B) 30 hpf wild type embryo has correctly polarized LPM with asymmetric migration. (C and D) 30 hpf has and nok mutants show loss of epithelial polarity and defective migration. (E) Schematic of (A) showing correctly polarized LPM and asymmetric migration. (F) has and nok mutant have identical morphogenetic phenotypes. Used with permission.|