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Mech Dev December 1, 2006; 123 (12): 881-92.

Xenopus cadherin-6 regulates growth and epithelial development of the retina.

Ruan G , Wedlich D , Koehler A .

Cadherins are crucial for tissue cohesion, separation of cell layers and cell migration during embryogenesis. To investigate the role of classical type II Xcadherin-6 (Xcad-6), we performed loss-of-function studies by morpholino oligonucleotide injections. This resulted in severe eye defects which could be rescued with murine cadherin-6. In the absence of Xcadherin-6, morphological alterations and a decrease in cell proliferation were observed with eye cup formation. Eye field transplantations of Xcadherin-6 depleted donors yielded grafts that failed to form a proper neuroepithelium in a wildtype environment. At later developmental stages Xcadherin-6 deficient eyes showed lamination defects in the outer neural retina, a reduced thickness of the ganglion cell layer (GCL) and a fragmented retina pigment epithelium (RPE). Thus, Xcadherin-6 is essential early in eye development for structural organization and growth of the neuroepithelium before it differentiates into neural retina and RPE.

PubMed ID: 17034995
Article link: Mech Dev

Genes referenced: actb actl6a cdh6 nppa rax rpe slc5a5 tbx2
Morpholinos: cdh6 MO1

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