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XB-ART-34456
Dev Biol. November 15, 2006; 299 (2): 411-23.

ADMP2 is essential for primitive blood and heart development in Xenopus.

Kumano G , Ezal C , Smith WC .


Abstract
We describe here the cloning of a new member of the TGF-beta family with similarity to the anti-dorsalizing morphogenetic proteins (ADMPs). This new gene, ADMP2, is expressed in a broad band of mesendoderm cells that appear to include the progenitors of the endoderm and the ventral mesoderm. Antisense morpholino oligonucleotide knockdown of ADMP2 results in near-complete disruption of primitive blood and heart development, while the development of other mesoderm derivatives, including pronephros, muscle and lateral plate is not disrupted. Moreover, the development of the primitive blood in ADMP2 knockdown embryos cannot be rescued by BMP. These results suggests that ADMP2 plays an early role in specifying presumptive ventral mesoderm in the leading edge mesoderm, and that ADMP2 activity may be necessary to respond to BMP signaling in the context of ventral mesoderm induction.

PubMed ID: 16959239
Article link: Dev Biol.
Grant support: HD41434 NICHD NIH HHS

Genes referenced: a2m act3 actl6a admp admp2 bmp2 bmp3 bmp4 bmp7.1 hba3 lhx1 myod1 nkx2-5 nodal1 nodal2 t tal1 tgfb1 tnni3 tuba4b

Morpholinos referenced: admp2 MO1


Article Images: [+] show captions

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