Climbing the Greatwall to mitosis.
Greatwall kinase is a conserved regulator of mitotic entry, and new work in Xenopus egg extracts (Yu et al., 2006) shows that Greatwall is required for the positive feedback loop that removes inhibitory tyrosine phosphate from the central mitotic regulatory kinase Cdc2.
PubMed ID: 16630886
Article link: Mol Cell.
Genes referenced: cdk1 mastl pold1