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XB-ART-34784
FEBS Lett 2006 Nov 13;58026:6254-8. doi: 10.1016/j.febslet.2006.10.029.
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The first potassium channel toxin from the venom of the Iranian scorpion Odonthobuthus doriae.

Abdel-Mottaleb Y , Clynen E , Jalali A , Bosmans F , Vatanpour H , Schoofs L , Tytgat J .


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The very first member of K(+) channels toxins from the venom of the Iranian scorpion Odonthobuthus doriae (OdK1) was purified, sequenced and characterized physiologically. OdK1 has 29 amino acids, six conserved cysteines and a pI value of 4.95. Based on multiple sequence alignments, OdK1 was classified as alpha-KTx 8.5. The pharmacological effects of OdK1 were studied on six different cloned K(+) channels (vertebrate Kv1.1-Kv1.5 and Shaker IR) expressed in Xenopus laevis oocytes. Interestingly, OdK1 selectively inhibited the currents through Kv1.2 channels with an IC50 value of 183+/-3 nM but did not affect any of the other channels.

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Species referenced: Xenopus laevis
Genes referenced: kcna2 kcna5